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Carcinogenesis Within a life span carcinogenicity study carried out in B6C3F1 mice, methylphenidate induced a rise in hepatocellular adenomas, and in males only, a rise in hepatoblastomas at a day-to-day dose of somewhere around sixty mg/kg/working day. This dose is about 2 moments the MRHD of 60 mg/day specified to small children on mg/m2 foundati